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| FAQ |
What is Toll-like receptor?
Toll-like receptors (TLRs) are a class of transmembrane receptors that recognize conserved molecules shared by microorganisms, but distinguishable from host molecules, collectively referred to as pathogen-associated molecular patterns (PAMP)
Why to study TLRs of buffalo and goat ?
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India has a large genetic diversity with respect to buffalo and goat and hence the onus is on India to characteize this genetic diversity in terms of immune molecules such as TLR genes. There is paucity of information on the sequences, expression profiles, ligand specificity and their induced cytokine profiles in different breeds of buffalo and goat.
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Genetic characterization of the TLRs, their expression levels in the different tissues will give more insight into the disease resistance characteristics of Indian breeds of buffalo and goat.
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What are all the breeds of buffalo and goats to be studied ?
Buffaloes : Murrah, Toda and Assamese
Goats : Barbari, Black Bengal and Kanniadu
Why Midhun and Yak ?
Yak (Bos grunniens) and Mithun (Bos frontalis) belong to the Bos family, but very little is known about their evolutionay lineages especially with respect to their immune molecules such as toll-like receptors. No information is available on the presence of TLRs and their sequence characteristics in them. Once this information is generated, more understanding would be obtained about the evolutionary relationships of these animals with bovine.
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